Oral health has thus been identified by the World Health Organization as one of the top ten standards of human health. Oral ulcers are a highly prevalent mouth disease interfere with eating and speaking with different degrees of impact on the health of the whole body. We aim at investigating the role of mucoadhesive mouth patches, formed by electrospinning reduced graphene oxide containing polymer mats, for the treatment of mouth ulcer. This approach takes advantage of adhering to the ulcer site, thus delivering a drug locally and protecting the ulcer from mechanic stress, it prolongs the action of the drug, reduces the number of doses, and alleviates pain.