Mucoadhesive mouth patches for controlled
CH. KLEBER, S. SZUNERITS, R. WOITEK
Oral diseases, while largely preventable, pose a major health burden and affect people throughout their lifetime, causing pain, discomfort, and disfigurement.
Oral health has thus been identified by the World Health Organization as one of the top ten standards of human health. Oral ulcers are a highly prevalent mouth disease interfere with eating and speaking with different degrees of impact on the health of the whole body. We aim at investigating the role of mucoadhesive mouth patches, formed by electrospinning reduced graphene oxide containing polymer mats, for the treatment of mouth ulcer. This approach takes advantage of adhering to the ulcer site, thus delivering a drug locally and protecting the ulcer from mechanic stress, it prolongs the action of the drug, reduces the number of doses, and alleviates pain.
ACS Applied Bio Materials, 2022 5 (2), 771-778
The work is based on a recently accepted article on insulin delivery using mucoadhesive patches and together with the group for Medical Image Analysis and AI (MIAAI) at the DPU we are exploring different potential clinical applications including the delivery of glucagone for the reduction of bowel peristalsis during magnetic resonance imaging (MRI).
Photothermal Activatable Mucoadhesive Fiber Mats for On-Demand Delivery of Insulin via Buccal and Corneal Mucosa
~ CH. KLEBER, S. SZUNERITS, R. WOITEK ~