With each breath we exhale, thousands of molecules are expelled giving individuals a “breath-print”. Thanks to major breakthroughs in new technologies (electrochemical, chemiluminescence, plasmonic and others ) and the availability of mass spectrometers (MS), the field of breath analysis has made considerable advances. However, technical and statistical challenges have delayed until now the larger translation of exhaled breath technology for real-world applications.  We aim at  overcoming these challenges via the development of an efficient exhaled breath condensate (EBC) collection system based on engineered face mask design and the analysis of the protein content by RT-PCR as well as mass spectroscopy and different biosensor technologies, notable electrochemical and electrical based ones.